Treatment of Obstructive Sleep Apnea: Discussion (1)

To our knowledge, this is the first study to compare the effects of nasal CPAP and nasal oxygen treatment on the major sequelae of mild obstructive sleep apnea. The main findings of our study were that oxygen does not reduce the total number of sleep disordered breathing events compared to baseline or placebo, although CPAP certainly does. However, oxygen does improve nocturnal oxygenation as does CPAP With the exception of reduced number of arousals noted with CPAP, neither form of treatment significantly affected sleep architecture in this group of patients. Neither treatment significantly affected blood pressure or cardiac ectopy. Most surprising to us was the finding that nasal oxygen does not improve daytime sleepiness, whereas nasal CPAP improves daytime sleepiness significantly.
The heterogeneity of our subject population and small number of patients hindered our ability to determine effects of treatments on every abnormality that we investigated. However, despite these limitations, we were able to demonstrate significant changes in neuropsychologic function, daytime sleepiness, and SDB in this preliminary study. buy asthma inhalers
Several investigators have demonstrated that nocturnal oxygen improves oxygen saturation in patients who have SDB.– In a one-month study of 4 U min nasal oxygen and control of 4 L/min nasal cannula air, Cold and colleagues reported an improvement in oxygen saturation and decrease in apnea frequency in eight patients with primarily obstructive sleep apnea.


Category: Obstructive Sleep Apnea

Tags: cardiac arrhythmias, diastolic blood pressure, hypopnea, obstructive sleep apnea