Treatment of Obstructive Sleep Apnea (9)Statistical Analyses
Statistical procedures used for data analysis were a repeated measures analysis of variance (based on its robustness* *) to assess for treatment effects. Data were first analyzed using a one-way repeated measures ANOVA with die factor of treatment (baseline, air, oxygen, nasal CPAP). Posthoc comparisons of mean differences were accomplished with die Schefle test. Although we recognized the limitations of a small, nonrandom sample, a comparable nonparametric test such as the Kruskal-Wallis or Median Test was considered inappropriate given the repeated assessment of subjects over the three treatments used in this study.
Results
Patient characteristics are reported in Table 1. These patients are typical of those commonly encountered in clinical practice of sleep apnea: the majority are overweight and they are all men. In every patient, apneas were predominantly obstructive. buy levaquin online
Results of treatment of sleep disordered breathing and oxygen saturation are reported in Table 2. In general, nasal CPAP was more effective in reducing SDB events, but oxygen was more effective in improving oxygen saturation. Repeated measures analysis of variance on the number of apneas demonstrated significant results due to treatment (F[3,21] = 5.59, p<0.01). Posthoc tests showed that the mean number of apneas was significantly different for CPAP vs air (p<0.01) and marginally different for CPAP vs oxygen (p<0.06).

Table 1—Subjects

Subject,No. Age,yrs Height, cm (inches) Weight,kg (lbs) % Ideal Body Weight Years of Education InitialAHI InitialMSLT,

min

Initial Blood Pressure, mm Hg Initial Mean Low SaOt, %
1 64 182.8 (72.0) 92.2 (204) 120 9 38.3 10.1 154/86 86.1
2 67 177.8(70.0) 76.8(170) 106 14 12.0 10.4 146/106 92.1
3 58 167.6(66.0) 103 (228) 159 7 25.8 10.8 138/96 85.8
4 72 170 (67.0) 70.5(156) 106 21 17.7 18.4 148/98 92.5
5 52 182.8(72.0) 109.8(243) 143 20 8.7 8.3 156/96 94.8
6 43 189 (74.5) 155.9 (345) 186 16 17.7 14.8 142/112 90.4
7 67 174 (68.5) 68.7 (152) 97 19 6.0 16.9 174/92 96.5
8 33 179 (70.5) 156.3 (346) 209 14 34.4 5.5 136/90 71.6
Mean± 57 ±4.8 70.1 ±1.0 228.1 ±27.5 140.8 ±5.9 15.0± 1.8 20.5 ±4.8 11.9± 1.6

Table 2 — Sleep-Di9ordered Breathing and Oxygen Desaturation

Apneas Hypopneas AHI Mean High SaOs Mean Low SaO No. of Falls ^4% SaO,
Baseline 90.3 ±22.6 44.6 ±13.9 20.5 ±4.8 92.9 ±2.4 88.7 ±2.8 168.9 ±39.2
Air 144.0 ±37.0 12.1 ±6.7 22.1±5.7 94.2 ±0.8 89.9 ± 1.8 208.1 ±51.7
Oxygen 114.0 ±20.7 0.6±0.6 16.8 ±3.2 97.1 ±0.2 95.9±0.3 29.4±8.2
CPAP 20.6 ±7.9 2.6 ± 1.8 3.0±0.9 94.9±0.7 93.7 ±0.9 32.6± ll.l