Treatment of Obstructive Sleep Apnea (8)

Protocol
Subjects underwent a total of four evaluations (as described above), each separated by approximately one month (range 24 to 32 days) of treatment with air, oxygen, and CPAP. Following a baseline study, subjects were randomized to receive either nasal oxygen at 4 LPM, or nasal compressed air at 4 LPM, nightly for a month. The testing protocol was then repeated, and the subject then received a month of nocturnal treatment with the other gas. After a third testing protocol, all subjects received a third and final month of treatment with nasal CPAP; levels of nasal CPAP were established initially in the lab and then adjusted at home by a respiratory therapist, based on behavior during napping. The CPAP levels ranged between 2.5 and 12.5 cm HtO. The subjects then returned for a fourth and final study after a month of treatment with nasal CPAP. buy ampicillin
Thus, nasal oxygen and nasal air (placebo) were used in a randomized, crossover fashion. Nasal CPAP was always used last because it has a residual beneficial effect of unknown duration after its use is discontinued and is difficult to deliver in a blind fashion. The subjects, persons scoring polysomnographic data, and persons administering neuropsychologic tests were blind to the identity of the first two treatment gases (air or OJ, but were not, for obvious reasons, blind to when the patient received nasal CPAP


Category: Obstructive Sleep Apnea

Tags: cardiac arrhythmias, diastolic blood pressure, hypopnea, obstructive sleep apnea