Subjects were considered eligible for study if they had an apnea plus hypopnea index of ^5 and at least one of the following:
1. Daytime hypersomnolence with a mean sleep latency of ^10 minutes on multiple sleep latency testing.
2. Hypertension, with a mean of at least five measurements of either systolic blood pressure >150 mm Hg and/or diastolic blood pressure ^95 mm Hg.
3. Significant cardiac arrhythmias, including marked sinus arrhythmia, sinus bradycardia, frequent (>6 per hour) premature ventricular contractions, one or more sinus pauses >2 seconds associated with apnea or hypoxemia, or supraventricular tachycardia. ventolin inhaler
In attempts to include patients with mild sleep-disordered breathing, we excluded patients if AHI ^40 events/hour, initial MSLT <5 mins, mean high SaOs—mean low SaO* ^8 percent.
All subjects were snorers and all complained of excessive daytime somnolence. Patients were excluded if they had symptoms of lung disease. Subject 8 had an initial supine mean high Sa02 of 77.1 percent, but was never a smoker and had spirometry consistent with restrictive ventilatory defect due to obesity (FVC 3.36L, 66 percent of predicted, FEV,, 2.72 L, 64 percent of predicted, and FEV,/FVC, 81 percent), and a normal chest roentgenogram. Subjects with ^20 percent central apneas or hypopneas were excluded. Two exsmokers with current normal spirometry were included.
Category: Obstructive Sleep Apnea
Tags: cardiac arrhythmias, diastolic blood pressure, hypopnea, obstructive sleep apnea