Treatment of Obstructive Sleep Apnea (11)

Treatment of Obstructive Sleep Apnea (11)Some of the important measures of sleep architecture and sleep quality are presented in Table 3. Analyses of the sleep architecture and sleep quality measures generally showed nonsignificant treatment effects, including percentage of time spent in stages of sleep or sleep efficiency. A main effect of treatment was seen for the number of arousals associated with treatment (F[3,21] = 3.09, p<0.05), however. Posthoc analyses showed only a marginal mean difference between nasal CPAP and baseline arousals (p = 0.08).
Effects of treatments on blood pressure and ectopy are reported in Table 4. There was a tendency for both oxygen and CPAP to lower systolic blood pressure, although these changes were not statistically significant. Treatments were not effective in lowering diastolic blood pressure. Cardiac ectopy was unaffected by treatment. ventolin inhalers
Data directed assessing the effects of treatments on daytime sleepiness are presented in Table 5. The treatment main effect on mean MSLT data (F[3,22] = 6.22, p<0.01) showed that nasal CPAP significantly lengthened the MSLT time compared to baseline (p<0.05), resulting in a significant improvement in objectively measured daytime sleepiness. Nasal CPAP was also significantly more effective than oxygen (p<0.01) and marginally better than nasal air (p<0.06) in lengthening the MSLT.

Table 3—Sleep Architecture

%Stage 1 %Stage 2 %Stage 3 and 4 %REM NumberArousals Sleep Efficiency, %
Baseline 14.8 ±2.3 57.0±5.6 6.0± 1.2 13.9 ±3.0 202.6 ±66.8 87.2 ±2.1
Air 15.6 ±2.6 54.9 ±5.8 6.1±1.7 14.5 ±2.7 84.9±21.8 88.1±2.5
Oxygen 20.0 ±4.2 51.1±5.0 7.6±2.1 11.0±1.7 110.6± 1.7 86.9 ± 1.8
CPAP 19.3 ±5.0 46.3 ±3.9 8.0 ±2.2 16.3 ±2.6 70.8 ±16.6* 87.0 ±2.3

Table 4—Cardiovascular Data

Systolic Blood Pressure, mm Hg Diastolic Blood Pressure, mm Hg NumberPACs NumberPVCs
Baseline 148.9 ±4.4 96.6 ±3.0 66.4 ±39.6 241.6 ±214.5
Air 144.6 ±5.9 95.9 ±2.6 7.0±2.6 38.9±20.7
Oxygen 139.6 ±5.2 96.4 ±5.4 3.9± 1.5 20.3± 11.2
CPAP 140.8 ±4.5 94.6±2.9 8.0±7.0 9.3 ±4.3

Table 5—Sleepiness Data

MSLT Mean, min SSS
Baseline 11.9±1.6 2.4 ±0.2
Air 12.0 ±2.0 2.9 ±0.3
Oxygen 10.8 ±1.6 2.5±0.2
CPAP 15.1 ±2. It 2.5 ±0.3

Category: Obstructive Sleep Apnea

Tags: cardiac arrhythmias, diastolic blood pressure, hypopnea, obstructive sleep apnea