The Treatment of Cough (15)
Therefore, the clinical significance of the improvements seen with these two agents must await the results of additional studies that assess short-term and long-term effects on the patients condition. buy birth control online
While bronchodilators (eg, P-adrenergic agonists, theophylline, and anticholinergic agents) might theoretically improve the superficial velocity of cough by improving flow rates, these agents have not been evaluated, to our knowledge, as protussives. One of the reasons why it cannot be assumed that these agents will consistently increase cough effectiveness relates to the observation that flow rates may occasionally decrease, even in normal subjects, from too much smooth muscle relaxation of large airways. This presumably occurs when more compliant large airways narrow too much because they cannot withstand dynamic compression during forced expirations.
While there are a number of agents that can increase cough frequency with varying success and while these effects have been primarily used to induce cough in animals and human volunteers in order to evaluate the effectiveness of antitussive drugs and better understand the pathogenesis of cough, we are unaware of any of the following being studied as a potentially clinically useful protussive: (1) drugs that inhibit angiotensin-converting enzyme.