Tag: Airway responsiveness

Studies dealing with occupational exposures as diverse as colophony fumes, crab processing, isocyanates, and western red cedar reveal that only about 20% to 40% of patients will experience a gradual disappearance of their airway hyperresponsiveness after removal from the exposure for periods of one to six years. Improvement in responsiveness correlates with the duration and […]

Population-based studies are consistent in reporting an accelerated rate of decline in FEV, in adult asthmatic subjects relative to normal individuals (Table 8).* With the exception of work by Fletcher et al, these studies do not adjust for baseline level of lung function, nor do they consider possible interactive effects of asthma with other symptoms. […]

These clinical measures remain largely unstudied in adults, and their relationship to prognosis is unknown. Equally unclear is their relationship to epidemiologic measures of disease severity. An additional potential problem with clinical measures of severity is that they may be influenced by access to medical care. buy asthma inhalers In summary, a large number of […]

Zetterstrom et al first proposed this hypothesis when studying 129 coffee-roasting workers. They found that smokers were more likely to have positive skin tests to coffee beans and castor beans than nonsmokers. Smokers have been shown to be more likely to have specific IgE to a variety of other occupational antigens such as ispaghular extract, […]

The subjects with negative skin tests were older, had a shorter duration of asthma, had lost more time from their usual activities, and had more frequent doctor visits than did the group with positive skin tests. When adjusted for age and duration of asthma, however, the 2 groups appeared similar with regard to asthma severity. […]

Woolcock et al studied 876 adults (mean age, 49). Subjects were considered to be responsive if their FEV, decreased by 20% with ^3.9 mol of histamine. Females (13.7%) were more likely to respond than males (8.9%). Finally, Rijcken et al studied 1,905 adult subjects (mean age, 35) in The Netherlands. A nonsignificantly greater percentage of […]

These clinical studies are subject to a variety of important biases. They deal with a small number of selected cases, often poorly defined. They often are confounded by effects of treatment. No study adjusts for baseline level of FEV,, and no study uses multivariate techniques to assess the relationship of bronchial responsiveness to disease severity. […]

Level of lung function also correlates with other factors known to be associated with bronchial responsiveness such as cigarette smoking and age. Finally, level of lung function and increased airway responsiveness may be related because they are both manifestations of chronic airway inflammation. Although the majority of patients with chronic obstructive lung disease have both […]

In preparation for the writing of this paper, I reviewed 27,515 articles on asthma, published since 1968, through the use of the computerized bibliographic retrieval system, P&per Chase. Only 75, or less than 0.05%, mentioned severity, and only 14, or 0.005%, mentioned impairment. Disability was mentioned in 63, or less than 0.05%. Over half of […]

These indices were compared in 3 groups of subjects: (1) a wheeze group, which included subjects with current persistent wheeze and/or dyspnea of grade III or higher or attacks of shortness of breath with wheeze, (2) a cough and phlegm group, consisting of subjects with chronic cough and/or chronic phelgm and/or episodes of bronchitis, and […]