Respiratory Failure of Acute Organophosphate and Carbamate Poisoning: Discussion (1)Acute organophosphate poisoning was the most common type of poisoning in Taiwan. The major cause of poisoning in our study was attempted suicide (65.4 percent); this kind of patient always had more severe poisoning because the amount ingested was larger than the other types of exposure, such as accidental ingestion or skin contact. This accounts for the fact that nearly half our patients had more severe poisoning and a higher mortality rate (20.6 percent) than in other studies.- buy ortho tri-cyclen online
The respiratory symptoms of the muscarinic effects, including rhinorrhea and bronchial secretion, bron-chospasm, and laryngeal spasm, may develop, which can result in airway obstruction. The respiratory symptoms of the nicotinic effects are associated with paralysis of the respiratory muscles. Weakness of the muscles of the tongue and pharynx aggravate the upper airway obstruction. Finally, there may be a central depression of respiration leading to cessation of breathing. This is thought to be a result of direct action of the organophosphate at the cholinergic synapses in the brain stem that are involved in the control of respiration.