Respiratory Failure of Acute Organophosphate and Carbamate Poisoning (1)Because of the widespread use and availability of agricultural insecticides, suicidal or inadvertent poisoning became a common and serious problem in Taiwan. The mortality of organophosphate varied from 10 to 86 percent, staying from 10 to 20 percent during the past ten years with intensive care management, such as large-dose atropine and pralidoxime therapy, as well as ventilator support for respiratory failure (RF).- The cause of death was thought to be a combination of excessive bronchial secretions, pulmonary edema, bronchospasm, respiratory muscle paralysis, and paralysis of the respiratory medulla, summarily, “RF.”V7 This study consists of 107 patients with acute organophosphate or carbamate poisoning whose RF was analyzed according to different onset times. Associated disorders, such as cardiovascular collapse and pneumonia, are discussed. buy prednisone
Materials and Methods
One hundred seven patients were admitted to Chang Gung Memorial Hospital with the diagnosis of acute organophosphate or carbamate poisoning during the period 1982 to 1987. All patients received first aid and farther treatment at this medical center; referred patients were excluded from this study to avoid the confusion in data analysis.