Quality of Life in Patients with Obstructive Sleep Apnea: nCPAP treatment
None of these variables had any significant bearing on the changes in SF-36 parameters with nCPAP treatment. However, significant correlations were found between quality of life scores on the SF-36 at baseline and prior to nCPAP administration and the subsequent change in scores after treatment, except for “role physical.” In other words, patients with lower scores and more impairments on the SF-36 before treatment demonstrated larger improvements in SF-36 domains after treatment (Fig 3).
Our study demonstrates that the quality of life in patients with OSA is severely impaired and can be improved with nCPAP therapy. All domains of the quality of life, from emotional and mental health functioning to vitality and physical health, were impaired by OSA when compared with the age-matched normal population. OSA impacted on the quality of life in various ways. Some patients with rather mild OSA reported the same degree of impairment in SF-36 domains, as did those with more severe cases of the disease. The diminished quality of life measures did not correlate with disease severity. Similar to the present study, other investigators have shown no correlation between the severity of sleep apnea, as defined by the number of apnea/hypopnea events per hour, and the health profile indices.- OSA is commonly associated with neuropsychiatric disturbances that could interfere with the capacity of the patient to fully appreciate the quality of his/her state of health. Canadian healthcare mall read only This could explain the lack of correlation between OSA severity and the self-perceived health status. Our data and the data mentioned above differ from the study of Tousignant et al, which demonstrated a correlation between RDI and pretreatment health state indicating the higher the severity of disease the lower the health status. The reason for this discrepancy may be because this study was conducted retrospectively and, therefore, may have been biased because of errors in recall about the pretreatment health state. Furthermore, there were some inconsistencies in the response to treatment in the aforementioned study. The respiratory indices and daytime sleepiness improved with treatment, although there was either worsening or no changes in some of psychological symptoms such as depression.
An optimal nCPAP level was achieved for all patients during the study. The use of nCPAP ranged from 3 to 8 h/night for the duration of study. After 8 weeks of nCPAP therapy, the SF-36 scores on mental health, social functioning, and vitality improved significantly and were no longer statistically different from normal age- and gender-matched subject scores.
Figure 3. The relationship between quality of life domains prior to nCPAP treatment and the degree of improvement in these domains after nCPAP treatment.