Quality of Life in Patients with Obstructive Sleep Apnea: Materials and Methods

Study Protocol
Prior to the onset of nCPAP therapy and “split-night” polysomnography, each patient completed a previously validated health questionnaire, the Medical Outcomes Study Short Form-36 (SF-36), and baseline anthropomorphic measurements were recorded. The optimal nCPAP level was determined in the laboratory during the study. Eight weeks later, the SF-36 was readministered, and each patient answered additional questions concerning the number of hours per night and the number of times each week that they received nCPAP therapy. Compliance with nCPAP was based on self-reports.
Quality of Life Assessment
The SF-36 questionnaire measures how the patient perceives his/her own functional status, well-being, and overall health. The patients were also asked if they had stopped or reduced certain activities because of health or emotional problems, such as depression. They were also asked to assess how much their social activities had been curtailed by their health. The normative data for age- and gender-matched population were used for comparison.
Sleep Study
Polysomnography was performed between 9:00 pm and 7:00 am as previously described. Briefly described, the sleep state was recorded with two channels of electroencephalogram (C3/A2 or C4/A1, O2/A1 or O1/A2), two channels of electro-oculogram, and one channel of submental electromyogram. Breathing was assessed by monitoring chest wall and abdominal movements using strain gauge pneumographs, and nasal and oral flows were monitored using thermisters comments my canadian pharmacy online. Arterial oxygen saturation was measured using an oximeter (Biox 3700c; Ohmeda; Louisville, CO). Leg movements were monitored with two channels of electromyogram, and an ECG was recorded continuously. All variables were recorded simultaneously and continuously on a 16-channel polygraph (model 78D; Grass Instruments; Quincy, MA). Sleep recordings were scored in 30-s epochs and staged according to standard criteria. Calculated variables included the number of arousals, the respiratory disturbance index (RDI; apnea/hypopnea index), and the number and degree of arterial oxygen desaturations.


Category: Obstructive Sleep Apnea

Tags: nasal continuous positive airway pressure, quality of Life, sleep apnea