Pseudomonas aeruginosa Compared with Escherichia coli Produces Less Endotoxemia: Results (2)Comparison of Qualitative Hemodynamic Changes and Mortality
Serial changes in cardiovascular performance were observed during the course of the experiment in all infected dogs (Fig 2 and 3, data not shown for E coli 7 X 10P CFU/kg). Animals implanted with sterile clots, however, maintained their hemodynamic parameters within the normal range (Fig 2 and 3) throughout the study period (baseline, and days 1, 2, and 10 after surgery). To determine if the pattern of hemodynamic changes was similar for different bacteria, the Kendall coefficient of concordance (see “Methods”) was calculated for each parameter. The coefficient of concordance determines if graded hemodynamic responses occurred at similar time points in different groups. buy diabetes drugs
All infected dog groups (Table 1) were used in the comparison. A strong concordance was found for each of the serial hemodynamic parameters followed during sepsis: LVEF = 0.93 (p<0.01); MAP = 0.93 (p<0.01); cardiac index (Cl) = 0.78 (p<0.03); stroke volume index (SVI) = 0.85 (p<0.02); end-systolic volume index (ESVI) = 0.78 (p<0.03); and end-diastolic volume index (EDVI) = 0.68 (p<0.05). On day 2 of sepsis, after volume infusion (denoted by asterisks in Fig 2 and 3), all groups of infected dogs (including P aeruginosa), compared with baseline values, demonstrated a decreased LVEF (p<0.001), increased EDVI (p<0.05), and increased Cl (p<0.01). This cardiovascular profile is similar to the hyperdynamic response observed in human septic shock and has been previously described in this canine model for E coli and S aureus septic shock.