Pseudomonas aeruginosa Compared with Escherichia coli Produces Less Endotoxemia: Results (1)

Clinical Manifestations, Blood Cultures, and Laboratory Tests
As previously reported, the intraperitoneal implantation of infected clot produced fever and prostration in all animals.- Blood cultures grew the organism placed in the clot on days 1, 2, and 3 after surgery. Thereafter, blood culture positivity began to decrease. In survivors, blood cultures were sterile by seven days after the onset of infection. Control dogs with sterile clots were afebrile, had sterile blood cultures, and were healthy throughout the study. buy antibiotics online
Creatinine, urea, pH, and Po2 remained within the normal range for all study groups. Hemoglobin, sodium, potassium, bicarbonate, chloride, glucose, and calcium levels were similar in all infected dogs. The 200 cGy (total body dose) of cobalt 60-generated gamma radiation, given six days prior to E coli implantation (14 X 109 CFU/kg), resulted in marked leukopenia during sepsis. The day 1 peripheral white blood cell counts in E coli-infected dogs were 800± 143 and 16,200± 1,444/cu mm (mean ± SEM) in the irradiated and nonirradiated dogs, respectively (p<0.001). In 20 non-infected beagles, this dose of radiation produced a transient fall in the peripheral white blood cell count to 23 percent ± 5 percent of baseline values (p<0.005) over six to ten days, but no other manifestations of radiation injury.


Category: Pseudomonas aeruginosa

Tags: aeruginosa, endotoxin, sepsis, septic shock