In a previous study using this canine model, we demonstrated that S aureus produced a cardiovascular pattern of septic shock identical to E coli9 but in the absence of any detectable endotoxemia. This indicates that bacterial products other than endotoxin can activate a common pathway resulting in similar cardiovascular injury and mortality. The current investigation suggests that endotoxin may not be the universal, or even the most important, toxin in all infections caused by Gram-negative bacteria. These findings, taken together, support the hypothesis that a number of bacterial products can activate an endogenous mediator (such as tumor necrosis factor) or cascade that acts as the final common pathway to hemodynamic instability and death in septic shock. buy levaquin online
Pseudomonas aeruginosa is known to produce a number of proteases and exotoxins that may be related to its pathogenicity. Of these, exotoxin A, a potent inhibitor of protein synthesis, has been most closely linked to systemic toxicity and death. Exotoxin A is produced by about 90 percent of clinical P aeruginosa isolates, and naturally acquired antibodies to exotoxin A correlate with survival from P aeruginosa sepsis in humans.- Our finding of greater toxicity but lower endotoxin concentrations associated with P aeruginosa compared with E coli might be explained by the additive or synergistic action of exotoxin A. The P aeruginosa isolate used in these experiments, however, did not produce exotoxin A. This argues that additional, less well-defined, bacterial products may significantly contribute to the pathogenesis of the septic shock syndrome.
Category: Pseudomonas aeruginosa
Tags: aeruginosa, endotoxin, sepsis, septic shock