These findings suggest that bacterial products other than endotoxin can activate a common pathway that results in similar cardiovascular injury and mortality. If some Gram-negative bacteria produce non-LPS toxins capable of triggering this common pathway, then anti-endotoxin therapies might not be universally efficacious in all cases of Gram-negative septic shock. The clinical significance of plasma endotoxin concentrations during septic shock may also depend on host factors. Some patients may be more sensitive to the release of harmful endogenous mediators by endotoxin, and in others the presence of anti-LPS antibodies may be protective. An endotoxin challenge that is well tolerated by a healthy adult might result in shock and death in a host already compromised by injury or illness. Overall, the effects of underlying disease, immune suppression, and other variables on the consequences of endotoxemia are poorly understood. birth control pills
In this investigation using a canine model of septic shock, we compared the endotoxemia, cardiovascular abnormalities, and mortality produced by two different Gram-negative bacteria that frequently cause septic shock in patients, E coli and Pseudomonas aeruginosa. Further, we evaluated the effect of leukopenia, a host-related risk factor for infection, on the cardiovascular abnormalities and endotoxemia of Gram-negative septic shock.
Category: Pseudomonas aeruginosa
Tags: aeruginosa, endotoxin, sepsis, septic shock