RESULTS

Of the 378 samples tested, 90.4% were from females. The median age of patients was 56.3 years (range 23.6 to 91.9 years), and sera were stored for a median length of 7.2 years (range 0.1 to 10.5 years).

Ten (2.6%) samples (all from females) were found to be positive for IgA EmA. All of these samples had raised titres of IgA tTG (median 2400 AU/mL; range 230 to 17,440 AUC/mL), with a reference range of up to 140 AU/mL.

Forty-four (11.6%) samples (84.1% female) were negative for IgA EmA but had elevated titres of IgA tTG (median 200 AU/mL; range 142 to 505 AU/mL). The remaining 324 samples were negative for IgA EmA and had IgA tTG titres within the reference range (median 35 AU/mL; range 3 to 140 AU/mL). Three samples had tTG titres of below 5 AU/mL, but none demonstrated IgA deficiency. Get most advantageous deals ever – cialis professional 20 mg waiting for you round the clock.

The tTG titres of the EmA-positive and -negative samples are shown in Figure 1, and the demographic data are shown in Table 1.

Immunoglobulin (Ig) A tissue transglutaminase antibody (tTG) titres in 380 patients Figure 1) Immunoglobulin (Ig) A tissue transglutaminase antibody (tTG) titres in 380 patients with primary biliary cirrhosis (PBC). AU Arbitrary units; EmA Endomysium antibody

TABLE 1
Demographic data of patients with primary biliary cirrhosis

Sex

(F:M)

Age at time of study, median years (range) Duration of serum storage, median years (range)
EmA positive (n = 10) 10:0 56.1 (34.1-68.5) 7.9 (0.3-9.7)
EmA negative, tTG >40 AU/mL (n=44) 37:7 58.7 (32.6-91.9) 7.0 (0.1-10.3)
EmA Negative, tTG <140 AU/mL (n = 324) 295:29 56.0 (23.6-82.8) 7.1 (0.1-10.5)

Of the 10 patients who were positive for both antibodies, five had had a small bowel biopsy, and all showed evidence of CD, with a confirmed prevalence of 1.3%. None of the patients from the group with high tTG titres and negative EmA had been biopsied at the time of writing.