In our normal subjects, the mean AT determined by the modified V-slope differed from the mean AT estimated from the fall in plasma standard bicarbonate; a similar difference was found for the patients with COPD. With these differences in mind, we nevertheless believe that ability to determine the Vo2 at which metabolic acidosis occurs by the noninvasive V-slope method is useful. This is true largely because, especially in the COPD patients, it is often the presence or absence of metabolic acidosis during exercise that is the helpful differential diagnostic clue, and the modified V-slope method is satisfactory for our purposes in most individual exercise studies. whitening gel
The occurrence of metabolic acidosis in patients with COPD during exercise may be important for designing an appropriate rehabilitation program. For example, in those COPD patients who develop metabolic acidosis, exercise training has the potential to improve exercise tolerance. This is because a feature of exercise training in normal subjects is the amelioration of metabolic acidosis. Reduction of metabolic acidosis translates into reduced Ve requirement for the same amount of exercise and thus reduced exertional dyspnea. Exercise training can be recommended as a part of pulmonary rehabilitation with the specific objective of reducing ventilatory requirement during exercise. It follows that exercise training for individuals who do not develop metabolic acidosis will be unlikely to improve exercise capacity by this means, although other benefits of exercise may result. Thus, the finding of exercise metabolic acidosis in COPD patients may be useful in choosing exercise training as part of an individuals rehabilitation program.
An important proportion of COPD patients develops metabolic acidosis during exercise, which may contribute to exertional dyspnea and limitation of exercise capacity. Furthermore, a noninvasive gas exchange method for identifying the presence of metabolic acidosis was useful in normal subjects and in patients with COPD. The finding of metabolic acidosis in patients with COPD may prove useful in deciding whether to include exercise training as part of an individuals rehabilitation program.
Category: Pulmonary Disease
Tags: lung disease, metabolic acidosis, Pulmonary function