Home Nebulized Therapy for Patients with COPD: Compliance Data

Compliance Data
The mean compliance of the whole group was 57% (±34.3%) with individual compliance ranging from 0 to 124%. Figure 1 shows the frequency distribution of individual compliance. Thirty-six patients (44%) were compliant with their prescribed regimen (taking at least 70% of doses prescribed four times a day or at least 60% of doses prescribed five or more times daily). Forty-six (56%) were poorly compliant. Nebulizer use was also examined on a day-by-day basis. Figure 2 represents the days when patients did not use their nebulizer at all and shows that 17 patients (21%) took no treatment at all on at least 50% of days. Only eight patients took the correct dose on >80% days (Fig 3) and 50 patients followed their prescribed regimen on <20% of days. In 43 patients (52%), there were times when the nebulizer was switched on but no inhalation was recorded. For 36 of these, this happened only occasionally and there was a correlation between treatment time and inspiratory time. Seven patients (9%) showed no inhalation for >20% of the treatments recorded. Two of these were “compliant” and five were “poorly compliant.” Compliance was not related to number of doses prescribed per day (Fig 4).
Demographics
Compliance was not related to age, gender, duration of illness, socioeconomic class, marital status, or employment status.
Quality of Life Data
All patients completed the SGRQ at the start of the 4 weeks (SGRQ1). There was no correlation between percent compliance and any scores on the SGRQ1. Seventy-eight patients completed the SGRQ at the end of the study (SGRQ2); the mean scores for the subscales and correlations with compliance are shown in Table 1. The total scores on the SGRQ2 correlated negatively with percent compliance. Negative correlation was also found between percent compliance and scores on the symptom subscale and the impact subscale. sildenafil citrate pink

Figure 1. Frequency distribution of individual compliance.

Figure 1. Frequency distribution of individual compliance.

Figure 2. Day-by-day use of nebulizer: no treatment.

Figure 2. Day-by-day use of nebulizer: no treatment.

Figure 3. Day-by-day use of nebulizer: correct use.

Figure 3. Day-by-day use of nebulizer: correct use.

Figure 4. Relationship of compliance to number of daily doses.

Figure 4. Relationship of compliance to number of daily doses.

Table 1—Mean Scores of SGRQ Subscales and Correlation With Percentage Compliance

Subscale SGRQ1 SGRQ2
iMean iSD iMean iSD
Symptoms 71.39 17.81 68.03* 18.00
Impact 57.10 15.61 54.47f 15.46
Activity 81.47 17.37 81.67 16.45
Total 67.01 12.99 64.86* 13.42

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Category: COPD

Tags: COPD, home nebulized therapy, patient compliance