Multivariate analysis for the prognostic value of the expression of Le-related antigens: The majority of Lea-positive carcinomas were also positive for sialyl Lea antigen (98.6%; 68 of 69), and the majority of Lea-negative carcinomas were also negative for sialyl Lea antigen (84.4%; 27 of 32). There were no other strong correlations between the expression of other pairs of antigens. To avoid the problem of collinearity, the variable ‘expression of Lea antigen’ was excluded. Therefore, five variables (stage, histological type, sialyl Lea, Lex and sialyl Lex antigen expression) were included in the Cox’s regression analysis. Patients with Lex- or sialyl Lex-positive tumours had a worse survival outcome than patients with Lex- or sialyl Lex-negative tumours, respectively, separate from stage and histological type. The hazard ratio (HR) for Lex-positive to Lex-negative expression correlated with stage, that is, the HRs were 12.76 in stage I (95% CI 2.98 to 54.66), 0.63 in stage II (95%CI 0.14 to 2.88), 1.69 in stage III (95% CI 0.69 to 4.15) and 12.76 in stage IV (95% CI 2.98 to 54.66). In contrast to Lex expression, the HR for sialyl Lex-positive to sialyl Lex-negative expression did not correlate with stage (HR 2.90; 95% CI 1.01 to 8.37). Survival did not differ based on sialyl Lea expression in tumours (Table 2). This is your great chance – buy ampicillin online to take full advantage of best quality drugs.

Results of Cox’s regression analysis

Hazard ratio 95% CI
I 1.00
II 9.61 1.05-87.72
III 17.08 2.10-138.85
IV 16.34 3.36-79.56
Histological type
Well differentiated 1.00
Moderately differentiated 2.87 1.17-7.06
Poorly differentiated/mucinous 3.76 1.32-10.75
Sialyl Lea antigen expression
Negative 1.00
Positive 0.67 0.32-1.37
Lex antigen expression
Negative 1.00
Positive 12.76 2.98-54.66
In stage II* 0.050* 0.0070-0.34*
In stage III* 0.13* 0.024-0.72*
Sialyl Lex antigen expression
Negative 1.00
Positive 2.90 1.01-8.37

*Correlation between stage and Lewis (Le)x antigen expression