Expression of Lewisa, sialyl Lewis3, Lewisx and sialyl Lewisx antigens: RESULTS Part 1
Expression of Le-related antigens in normal colonic mucosa distant from the carcinoma: Of the 81 normal mucosa specimens distant from the carcinoma, Lea, sialyl Lea, Lex and sialyl Lex antigens were expressed in 74 (91.3%), 61 (75.3%), 48 (55.6%) and one specimen (1.2%), respectively.
Comparison of the clinicopathological features of patients with colorectal tumours that did or did not express particular Le-related antigens: Of the 101 carcinoma specimens, Lea, sialyl Lea, Lex and sialyl Lex antigens were expressed in 69 (68.3%), 73 (72.3%), 66 (65.4%) and 76 (75.3%) specimens, respectively (Table 1). There were no statistically significant relations between the expression of Lea, sialyl Lea or Lex antigen, and clinicopathological variables including age, sex, tumour location, maximal tumour diameter, histological type, TNM factor and stage. Buy cheap drugs online fast – generic viagra online pharmacy for you to enjoy a reliable pharmacy.
However, lymph node metastasis (N factor) was detected in 64.5% of the tumours that expressed sialyl Lex and in 32.0% of the tumours that did not express sialyl Lex – a significant difference (P=0.0056). Distant metastasis (M factor) was observed in 23.7% of the tumours that expressed sialyl Lex and in 4.0% of the tumours that did not express sialyl Lex – also a significant difference (P=0.037). The patients with tumours that expressed sialyl Lex antigen were in a significantly more advanced stage than those with tumours that did not express sialyl Lex (P=0.0029) (Table 1).
Distribution of patients with colorectal cancer that did or did not express Lewis (Le) , sialyl Le , Le or sialyl Le antigen according to the stage of carcinoma