Exercise Body Surface Potential Mapping in Single and Multiple Coronary Artery Disease: Discussion (Part 5)
That is, on average, a patient who exercises to angina with three-vessel CAD is likely to have a greater amount of ischemic myocardium than a patient with two-vessel disease who also exercises to angina. Moreover, the same reasoning suggests that a larger sample population of normal subjects may have allowed a statistically significant difference in exercise ST decrease among normal subjects and coronary patient groups 1 and 4.
Another limitation of this study was the application of the same BSPM quantitative methods to all subjects, irrespective of their spatial coronary anatomy. It seems reasonable that if spatial factors could be better controlled, for example by calculation of epicardial potential maps using standardized torso body geometry, better qualitative and quantitative correlations might result. This concept remains to be tested. ventolin inhaler
Overall, the results of the present study demonstrate that exercise BSPM provides a quantitative index of stress-induced ischemic myocardium. Further correlative studies with clinical outcome variables are warranted. The technique offers promise, however, in the selection and monitoring of CAD therapy based on objective and quantitative assessment of myocardium at ischemic risk, independent of symptoms and number of coronary arteries with atherosclerotic lesions.