Efficacy of Positive vs Negative Pressure Ventilation in Unloading the Respiratory Muscles (2)

In other words, NPV was of no additional benefit. Furthermore, it is now well documented that NPV may cause upper airway obstruction with apnea and oxygen desaturation in both normal subjects and patients with neuromuscular respiratory failure. Conversely, positive pressure ventilation (PPV) prevents upper airway obstruction during assisted ventilation and can be used noninvasively via a mouthpiece or nasal mask.
Most studies of NPV and PPV have not adequately documented that spontaneous inspiratory efforts were actually reduced during periods of AV Because the rationale for the use of intermittent assisted ventilation is based on the premise that it alleviates muscle fatigue, we believe it is essential to document that a significant reduction in ventilatory muscle activity can be provided. buy ampicillin
The purpose of our study was to compare the efficacy of short-term NPV arid PPV in reducing spontaneous diaphragmatic activity in awake naive subjects. Our results show that PPV applied noninvasively via a nasal continuous positive airway pressure (CPAP) mask is superior to negative pressure ventilation as a means of resting the diaphragm.


Category: Lung function

Tags: neuromuscular, neuromuscular disease, patients copd, ventilatory muscle