Effect of Antiallergic Agents and Bronchial Hypersensitivity in Short-term Bronchial Asthma (7)He was initially treated with beta-stimulant and xanthines for two weeks, and then DSCG was added. The PC20 was 836.2 |xg/ml when DSCG was started. This increased to 4,516.7 |xg/ml after two months, and to more than 10,000 jig/ml after five months. His asthmatic symptoms also disappeared in parallel with a decrease in the bronchial hypersensitivity. proventil inhaler

Discussion

Antiallergic agents are one of the main therapeutic drugs for the treatment of bronchial asthma. They are classified into two groups: the basic type (eg, ketoti-fen) which has an antihistamine activity, and the acidic type (eg, DSCG) which has no antihistamine activity. Recently, new antiallergic agents such as tranilast, repirinast, ibudilast (KC-404) have been produced in our country and have been utilized widely for the treatment of bronchial asthma. These agents have generated much enthusiasm, owing in part to pharmacologic effects which differ from those of the beta-stimulants or xanthines. Unfortunately, controversy exists concerning the effects of these agents on bronchial hypersensitivity. Some investigators report that ketotifen, DSCG, or tranilast are effective in reducing the bronchial hypersensitivity, while others report that those agents have no effect on bronchial hypersensitivity.