Effect of Antiallergic Agents and Bronchial Hypersensitivity in Short-term Bronchial Asthma (1)
Recently, various antiallergic agents such as disodium cromoglycate, ketotifen, tranilast, etc, have been used for the treatment of bronchial asthma. Bronchial hypersensitivity to specific and nonspecific stimuli has been well documented as one of the characteristic properties in bronchial asthma, and a high correlation between bronchial hypersensitivity and the severity of asthmatic symptoms has been reported. Although some reports” have been published concerning the effects of antiallergic agents on bronchial hypersensitivity, a consensus has not yet been established. In this study, we compared the histamine threshold before and after administration of antiallergic agents with no antihistamine activity and analyzed factors responsible for the improvement of nonspecific bronchial hypersensitivity. This report will demonstrate that antiallergic agents might be useful for the treatment of bronchial asthma patients, especially with short-term disease duration. buy flovent inhaler
Subjects and Methods
Subjects and Antiallergic Agents
Thirty-seven patients diagnosed with bronchial asthma were studied: 25 men and 12 women, 21 extrinsic and 16 intrinsic types. Their ages ranged from 21 to 79 years old (mean was 39 years), and all were nonsmokers.