T cell lymphoma

Our patient had 10 months of symptoms before the diagnostic segmental resection. Such a period would be significant for diminishing the published interval between disease onsets, if these processes are truly independent. Alternatively, we believe the processes arose synchronously, representing noninvasive and invasive elements of one lymphoproliferative disorder. Alleviation of symptoms in the absence of […]

When presenting in combination, 79% of refractory sprue subtypes will be monoclonal T cell proliferations with a poor prognosis. Refractory sprue and ulcerative jejunitis are now classified as cryptic ETL, due to their frequent CD3+, CD8- phenotype and monoclonal TCR gene rearrangements. However, whether isolated collagenous sprue is a monoclonal disorder remains controversial. Collagenous sprue […]

Celiac disease is a common illness with a prevalence of 1:150 to 1:350 in North America and Europe . The disease may be polygenic, with different genes parlaying gluten sensitivity in the varied patient populations. However, a specific HLA-DQ2 haplotype is seen in 95% of subjects. Classic presentations include fatigue, anorexia, diarrhea, abdominal pain, dyspepsia […]

Immunohistochemistry The neoplasm was positive for CD2, CD3, CD5, CD7, CD43, CD45RO and granzyme B. Rare anaplastic large cells were CD30+. Scant neoplastic cells were weakly positive for CD8. Lymphoma was CD4, CD10, CD20, CD15, Alk-1 and epithelial membrane antigen-negative.

Bowel mucosa had a prominent and confluent lamina propria lymphoplasmacytosis with abundant IELs. IELs of celiac disease mucosa were bland, small and readily exceeded 40 per 100 epithelial cells (a mean of 71.8 per 100 epithelial cells). Villous atrophy was near total in many histological sections and crypt hyperplasia was prominent. The ulcerated plaque was […]

Assessment of collagenous sprue intraepithelial lymphocytosis was via the established French Celiac Disease Study Group protocol . Three authors (SACM, SL, TC) analyzed at least five adjacent increments of 100 epithelial cells on CD3- and CD8-stained sections of collagenous sprue for IEL. An abnormal CD8 quantity (negative result) was defined as a 50% reduction in […]

Histological assessment Submitted bowel was fixed in 10% formalin, processed, paraffin embedded, sectioned and stained with hemotoxylin and eosin. Some sections were stained with Masson’s trichrome when superficial basement membranes of mucosa appeared thickened. Immunohistochemistry assessment

A 29.8 cm segment of bowel with central serosal fibrinous exudates was received for pathological examination. Midaspect serosa had adherent rubbery tissue deep to an annular 5.3×4.8×0.9 cm indurated mucosal plaque that was centrally ulcerated (Figure 1). Small areas of flattened valvulae con-niventes, the largest 2 cm in diameter, were separated from the plaque by […]

A 64-year-old man presented to the emergency room with 8 h of abdominal pain. Examination delineated an acute abdomen with maximum tenderness superior to the umbilicus. No mass, organomegaly or peripheral lymphadenopathy was noted. Radiological imaging verified viscus perforation with free air under the diaphragm and air-fluid levels of bowel obstruction. He relayed a 10-month […]

A prerequisite for the diagnosis of celiac sprue is a mucosal intraepithelial lymphocytosis. The constituent cells of intraepithelial lymphocytes (IEL) are predominantly cytotoxic T cells that express surface CD4, CD8 and T cell receptor (TCR)-P . An intraepithelial lymphocytosis can also be the histological correlate of refractory sprue . Such clinically unresponsive disease may also […]