Pulmonary Disease

In our normal subjects, the mean AT determined by the modified V-slope differed from the mean AT estimated from the fall in plasma standard bicarbonate; a similar difference was found for the patients with COPD. With these differences in mind, we nevertheless believe that ability to determine the Vo2 at which metabolic acidosis occurs by […]

Further, in patients with COPD with limited ability to increase Ve, the additional C02 produced may not be easily eliminated; this can lead to an elevation in arterial Pco2. We found that those patients who developed metabolic acidosis during exercise tended to have a higher mean exercise Ve and, possibly more important, tended to use […]

Anaerobic Threshold in Patients with COPD: Table 5 compares the AT determined by the two methods in the COPD patients. In 10/14 patients with a fall in standard bicarbonate ^2.5 mEq/L, the V-slope method indicated the presence of metabolic acidosis; the log standard bicarbonate method was successful in identifying all 14 of them. One patient […]

Normal Subjects The mean values for age, size, and pulmonary function of the 56 normal subjects are shown in Table 1. As described above, all had normal pulmonary function. Exercise capacity expressed as maximum oxygen uptake as percent predicted value and AT as determined by both the modified V-slope method and from changes in standard […]

Anaerobic threshold was determined by two methods: (1) modification of the V-slope method of Beaver et al; and (2) the Vo* at which there was a fall in plasma standard bicarbonate. The latter was determined for all tests by one observer who estimated the Vo* at which log standard HC03~ was seen to decrease from […]

A group of 22 patients with moderately severe to severe COPD Was studied. For comparison, a group of 56 subjects was identified pbm a previous study of the cardiopulmonary responses of normal filen during cycle incremental exercise. These subjects had no Evidence of heart, lung, peripheral vascular or musculoskeletal disease and were not anemic. As […]

Use of the V-slope Method for Anaerobic Threshold Determination Patients with chronic obstructive pulmonary disease (COPD) generally have limited exercise capacity because of reduced ventilatory capacity. During a progressive exercise test, for example, a patient with COPD will reach his maximum work rate and be unable to continue exercise when the minute ventilation (Ve) is […]