Prednisone therapy

Corticosteroids have also had beneficial effects when used intralesionally for strictures elsewhere in the gastrointestinal tract. In the esophagus, these benefits seem to occur regardless of the initial cause of stricture formation. In the present case, an oral loading dose was used, followed by a maintenance dose for four and a half months, resulting in […]

With the limited data available, discontinuing NSAIDs seems to be an obvious first step in patients who develop colonic strictures secondary to the use of this medication. This is supported by the fact that two patients went on to require surgery due to complications of restarting NSAIDs. Beyond that, the advice to give patients is […]

Data are scarce on the management and follow-up of this condition. Publications on eight of the 33 previous cases provide no details on treatment or follow-up. Twelve cases were managed with surgical resection; four with endoscopic dilation and nine were managed conservatively by discontinuing NSAID therapy as the sole therapeutic maneuver. Surgical resection has been […]

Colonic diaphragm formation is a rare and poorly understood side effect of NSAID use that can have serious consequences. Many NSAIDs have been associated with this complication, but most followed the introduction of extended-release NSAIDs and a disproportionate number have occurred with enteric-coated diclofenac preparations. Chronic NSAID-induced colonic ulceration may persist because of antibodies to […]

Because her duodenal lesions had resolved with no obvious change of her colonic lesions, 5-aminosalicylic acid treatment was discontinued and an empiric course of prednisone was given at an initial dose of 40 mg per day. She was discharged to a convalescent hospital and given intensive rehabilitation in preparation for knee replacement surgery. Because her […]

Gastroduodenoscopy and colonoscopy were carried out on April 21, 2002, and April 25, 2002, respectively. Gastroscopy revealed a diffusely erythematous antrum and body, which were biopsied and found to be histologically normal with no evidence of Helicobacter pylori. On duodenoscopy, four ulcers were found, three of which were clean-based and approximately 1 cm in diameter. […]

A 69-year-old woman developed left lower quadrant pain that gradually intensified over a period of four months. She then began passing two to three melena stools per day for four days and presented to the hospital with ongoing pain, fatigue, weakness and profound anemia. Her symptoms were associated with increasing anorexia and an associated 14 […]

Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly prescribed medications with significant toxicities. Although they are best known for gastric and duodenal ulceration, they have also been implicated in the development of colonic complications including ulcerations, colitis-like syndromes and complications of diverticular disease. Further evidence links NSAID use to the development of collagenous colitis. A rare but […]