Lung Disease

This can be attributed to the large individual night-to-night variability in levels of desaturation and amount of REM sleep which we have seen in such patients. Only one night (post acclimation) of sleep data was used to test these correlations in the present study. We in no way imply that one, two, or even three […]

One could postulate additional periods other than nocturnal desaturation or an intermediate step active even when Sa02 is at baseline. Eicosanoids including arachidonic acid, leukotrienes, thromboxanes, and prostaglandins are potent vasoconstrictors and may be elaborated by aggregated platelets or leukocytes. Perhaps transient hypoxemia induces deposition of platelets in the pulmonary arteriolar endothelium which leads to […]

Thus, there was no basis on which to infer a difference in the structure of the pulmonary parenchyma. Differences between groups in variables marking hematopoietic effects of hypoxemia persisted. Hemoglobin and RBC mass per kilogram in the 13 matched NOD subjects remained nearly identical to values derived for the entire group of 36 and higher […]

These data are compatible with two hypotheses. First, it is possible that the groups differ because of functional characteristics of the lung parenchyma that cause worsened ventilation/perfusion (V/Q) matching, daytime hypoxemia, and a greater propensity toward NOD. The recurrent nocturnal transient elevation of Ppa* and to some extent, the relative daytime hypoxemia, may then lead […]

The goal of this study was to determine whether there were differences in parameters of cardiopulmonary function between two subsets of patients with chronic lung disease. Since the predominant lung disease pattern was obstructive, FEV! was chosen as a parameter for matching groups. Numerous studies show that in obstructive lung disease, FEVi correlates with clinical […]

Since the groups were selected on the basis of NOD, mean sleep and nadir Sa02 for the NOD group was predictably lower than that for the non-NOD group (Table 3). Total sleep time was slightly lower in the NOD group. Mean time in bed, total REM, and NREM sleep time were not different between groups. […]

Differences in variables between NOD and non-NOD subjects were compared using a Students f-test for unpaired data. Pearson product moment correlations were used to examine parameter interrelations. Mean Ppa and PVR were compared to selected measures of daytime and nocturnal oxygenation using linear regression. The protocol was approved by Human Research Committees at the Houston […]

Pulmonary artery pressure (Ppa) and continuous central venous oxygen saturation (SvO*) were measured with the patient in the supine position using a balloon tip fiberoptic catheter introduced percutaneously through a peripheral vein or the internal jugular vein. Pressure transducers were leveled to the midthorax. Resting Ppa and pulmonary capillary wedge pressure (Pew) were obtained over […]

Croup 1 consisted of 36 subjects with chronic lung disease and REM sleep-related NOD discovered during nocturnal polysomnography. The NOD was defined as follows: (1) a baseline awake and non-rapid eye-movement (NREM) ear oximeter saturation of ^90 percent; (2) a fall below this value for five minutes or more, usually coinciding with but not limited […]

Forty-nine male veterans with chronic lung disease were recruited from the Houston Veterans Administration Medical Center chest medicine clinics to participate in this study. None had clinical evidence of chronic cor pulmonale. None showed substantial left ventricular dysfunction by gated equilibrium radionuclide ejection fraction (<45 percent = dysfunction). Chronic lung disease was defined by a […]