Diabetes and male sexual function

Sympathomimetic agents may be useful in the treatment of retrograde ejaculation. They act to stimulate the contraction of the bladder neck, prostate, seminal vesicles and vasa deferentia. Imipramine hydrochloride (75 mg bid), a tricyclic antidepressant that blocks norepinephrine reuptake at nerve terminal and potentiates peripheral adrenergic activity, may be the best agent to treat retrograde […]

Diabetes ejaculatory dysfunction The ejaculation reflex is initiated by cerebral erotic input and by sensory stimulation of the penis. The sensory afferent nerves are the dorsal nerves of the penis. Ejaculation is primarily a sympathetic event. The efferent neural pathways arise from spinal levels T10 to L2 and travel through the sympathetic chain ganglia, the […]

VEDs have been found to be effective in up to 75% of diabetic men. In many patients with diabetic impotence, a significant vascular component exists that renders ICI ineffective. In a male study of ICI failures, when a VED was used in 10 patients, five patients were able to have satisfactory sexual intercourse with this […]

Buy diabetes drugs ED, oral therapy is the best first line treatment. Currently, the only effective oral treatment is sildenafil, provided that there are no specific contraindications. In a large double-blind placebo study of 268 diabetic men with ED, erections were improved in 57% of patients who received sildenafil compared with 10% of men who […]

The clinical affect of DM on penile blood flow has been well documented. Patients with insulin-dependent diabetes and associated coronary artery disease have significantly more severe disease related to the cavernosal artery than noninsulin-dependent diabetic patients. Benvenuti et al proposed that, in diabetic ED, vascular obstruction is a more important factor than nerve damage. The […]

Although autonomic nerve testing is found to be abnormal in up to 63% of patients with diabetic ED, some studies have shown no difference from control values. NO has been identified as the principal neurotransmitter causing the relaxation of penile cavernous smooth muscle. This smooth muscle relaxation increases arterial blood flow and produces an erection. […]

Acute hyperglycemia alone may induce endothelial dysfunction and also decrease the velocity of nerve conduction in rodents. Chronic hyperglycemia is associated with the loss of myelinated and unmyelinated fibres and attenuated nerve fibre regeneration. Diffuse abnormalities of the peripheral nerve vasculature (vasa nervosum) are well documented in diabetics. In the late stages of diabetes — […]

ED is often associated with microangiopathy; thus, the presence of retinopathy is usually a good predictor of ED. Age, duration of DM and the presence of other diabetic complications correlates more with its future development. Between the ages of 40 to 70 years, the prevalence of ED is 52% for the general population, whereas in […]

Sexuality is an important aspect in the lives of most individuals and couples. Normal sexual function involves, however, the interaction and coordination of multiple components, including psychological, physiological, social, religious and emotional factors. Chronic medical conditions, such as diabetes, may have an impact on many of these components, not only physiologically, but also psychologically.