Abnormal Airway Function in Individuals with the Acquired Immunodeficiency Syndrome

Abnormal Airway Function in Individuals with the Acquired Immunodeficiency SyndromeIndividuals with the acquired immunodeficiency syndrome (AIDS) are subject to frequent often fatal pulmonary complications. Infections 4*4e to a myriad of opportunistic and common pathogens as well as noninfectious processes such as majignancy and lymphocytic interstitial pneumonitis have been identified in this setting. In addition, anatomic obstruction of upper and central airways may occur as a result of endobronchial metastases from Kaposis sarcoma. A bronchospastic disorder also has been described in 3 percent of 130 individuals with AIDS. In our experience, bronchospasm occurs jnore frequently in AIDS than has previously been reported. Symptoms such as wheezing and chest tightness are common among those in our AIDS patient population. The recognition of an asthma-like syndrome in AIDS is particularly important since it could be confused with life-threatening disorders such as opportunistic infection and could lead to either inappropriate diagnostic evaluation or therapy. To document the prevalence of airway dysfunction in this setting, wej analyzed pulmonary function test results and reviewed the medical records of individuals with AIDS ;who were treated at the New England Deaconess Hospital. canadian drug mall

Sample Selection and Testing Procedures

The New England Deaconess Hospital is a 500-bed university-affiliated hospital in Boston where approximately $5 percent of all those in Massachusetts with AIDS have received treatment since 1983. Between January 1, 1983, and July 31, 1986, 153 individuals with AIDS were treated at this institution. Of these individuals, 105 were referred to the pulmonary function laboratory. In all cases, the diagnosis of AIDS was established by the criteria outlined by the Centers for Disease Control. The records of all patients able to perform three forced expiratory maneuvers conforming to the standards established by the American Thoracic Society were evaluated. To qualify for analysis, each patient had to have an acceptable forced vital capacity as registered on a pneumotachometer-based spirometer (System 1070, Medical Graphics, St Paul, MN). This system was tested with a calibrated rotameter and its output was determined to be linear in the normal range of human forced expiratory flows. The system was calibrated twice daily by injecting a standard volume at five different flow rates. Spirometric values were compared with the published normal values of Crapo et al.

Category: Airways

Tags: AIDS, airway function, pulmonary, respiratory