A point mutation in the iron-responsive element of the L-ferritin gene (Part 2)

The role of the IRE is to interact with the cytoplasmic iron-responsive proteins (IRP) to regulate ferritin synthesis in response to cytoplasmic iron pools. When iron pools are adequate, the binding of the IRP to the IRE prevents the recruitment of the small ribosomal subunit to the mRNA, thereby, inhibiting the initiation of translation. The IRE is not unique to L-ferritin but is also found in H-ferritin, the 3′ region of the transferrin receptor mRNA and the ery-throid aminolevulinate synthase mRNA. Mutations in the IRE have been shown to decrease its affinity for the IRP, leading to the unregulated, constitutive synthesis of the L-ferritin mRNA, irrespective of the body’s iron status. This change in affinity has been demonstrated in vivo with lymphoblastoid cell lines and in vitro using thermodynamic analysis. Ferritin is normally expressed in the lens and is thought to function as an antioxidant. It is the overproduction of L-ferritin resulting in intracellular accumulation in the lens that is thought to lead to the formation of cataracts in HHCS. You have a great opportunity to discover the pharmacy that will always be sure to live up to your highest expectations, no matter if you would like to get buy Tavist online or buy any other prescription medicine with no prescription required on very advantageous terms.

Category: L-ferritin gene

Tags: Cataracts, Hyperferritinemia, Iron-responsive element, L-ferritin

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